I have to send regular newsletters to about 10.000 adresses.. now I cant exactly do this using my mail program. What professional solutions are there if also Id like to manage my adresses, categorize them etc.

Any help will be much appreciated

MySQL database with list of addresses.

Simple PHP script to read the addresses from the database and send the newsletter out to all those addresses.

You can set your own PC up as a server for this.

Investigate XAMPP